Challenging traditional historiographical approaches, this book offers a new history of Italian Jews in the early modern age. The fortunes of the Jewish communities of Italy in their various aspects – demographic, social, economic, cultural, and religious – can only be understood if these communities are integrated into the picture of a broader European, or better still, global system of Jewish communities and populations; and, that this history should be analyzed from within the dense web of relationships with the non-Jewish surroundings that enveloped the Italian communities. The book presents new approaches on such essential issues as ghettoization, antisemitism, the Inquisition, the history of conversion, and Jewish-Christian relations. It sheds light on the autonomous culture of the Jews in Italy, focusing on case studies of intellectual and cultural life using a micro-historical perspective. This book was first published in Italy in 2014 by one of the leading scholars on Italian Jewish history.